The former oratory was the seat of the ‘Confraternita disciplinata della Misericordia’ founded in 1348 and which for about ten years gathered in other places, until they built new headquarters in the houses of Tomasuccia di Puccio di Bartolo from Spello. The friars began to carry out hospital activities in 1386 and established their hospital in 1570. It was the only centre offering medical assistance in Spello, due to the suppression of similar services in San Michele Arcangelo and San Bernardino. In the second half of the 19th century the building became private property and was used as a woodshed, then a carpenter’s workshop, and subsequently became totally unusable after the 1997 earthquake. It is currently owned by a family from Spello but is in very poor condition, at risk of collapse and access is prohibited to the public.
Despite the most varied uses that have been made of it, traces of frescoes remain both on the exterior of the facade and inside, which is based on a rectangular floor plan with apses.