The fascinating Romanesque church of Sant’Andrea was built in 1025, probably by San Romualdo and was later sold, together with the annexed convent, to the minor friars by the bishop of Spoleto. The dedication to the Blessed Andrea Caccioli, a native of Spello and follower of St Francis, is of a later date. The building was modified via numerous interventions, until the last in the 17th century.
It is a Latin cross church with a unique, incredibly atmospheric nave and a treasure trove of works of art. It was restored by the Spello-born Benvenuto Crispoldi in 1913. Inside we find the Cappella del Battistero, the first Baglioni chapel, commissioned by Grifonetto Baglioni, who is portrayed there, in the 15th century. In the right-hand transept there is a beautiful panel by Pintoricchio, which he began in 1506, but which was completed in 1510 by Eusebio da San Giorgio and others. The letter by Bernardino di Betto at the base of the work is interesting because he justifies his abandonment of work due to impending commitments to Siena.
The altar is a precious sculptural artefact dated between the 13th and 14th centuries and houses, inside a gilded wooden urn, a relic of the Blessed Andrea Caccioli.
The convent stands next to the church and is entered via a portal to the right of the facade; a corridor connects the church to the cloister and the refectory and the other conventual areas overlook it.