The Abbazia di San Quirico is in the Cerreto area and was the residence of Benedictine monks from the 1st to the 19th century. Together with the abbey of San Crispolto della Piana, it was the main Benedictine settlement in Bettona in the early Middle Ages and the first documents attesting to its existence date back to 1185, while we have no information about its foundation, which is presumed to be prior to the year 1000. There are no documents referring to San Quirico in the 13th century, although we know that at the beginning of the 14th century it depended on the abbey of San Giuliano di Spoleto. It was a flourishing centre throughout the century, administering numerous estates and functioning as a large agricultural concern. Subsequently it was subject to raids by troops from Perugia and by king Ladislaus of Naples, right up to the beginning of its decline: in 1325 the pope incorporated San Quirico into the Duchy of Spoleto and subsequently granted it in commendam to the monk from Chiaravalle, Ugolino Baglioni.
Today the abbey is private property and the church, which was built on the ruins of the monastery, is completely bare. It was built with materials taken from the nearby Roman settlement Urbinum Hortense. Above the door of the church there is a fresco depicting a Madonna and Child with the Saints Crispolto and Quirico attributed to Cesare Sermei, an 17th-century Umbrian painter.